Impact of Cannabis Exposure on Gut Barrier Function in Metabolic Health and Disease

Дата публикации: 04-08-2026 00:00:00

The endocannabinoid (eCB) system is a lipid-derived signaling pathway that regulates food intake, energy homeostasis, and reward, and is expressed throughout the gastrointestinal tract. In diet-induced obesity (DIO), the eCB system becomes dysregulated and may contribute to impaired gut barrier function; however, it remains unclear whether activation of this system by cannabis is protective or detrimental. Previous studies suggest that intestinal epithelial CB1 receptors (CB1Rs) regulate gut barrier integrity and inflammation, yet conflicting evidence exists regarding the effects of cannabinoid signaling on intestinal permeability.To address this, we examined the impact of Δ9-tetrahydrocannabinol (THC) and whole cannabis extracts on gut barrier function in male and female mice with conditional deletion of CB1Rs in the intestinal epithelium (intCB1R-/-) and control mice (intCB1R+/+). Mice were maintained on either a low-fat standard diet or a Western diet (WD) for 60 days. Intestinal...

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