San Francisco 49ers quarterback Brock Purdy (13) takes the field at Levi's Stadium in Santa Clara, California, Sunday, September 27, 2026. IMAGN IMAGES via Reuters Connect

The 49ers started this season like they have something to prove.

There was a point just before the season started when the NFC West was seen as a lock for the Rams, and if not them, the reigning champion Seahawks would take the crown.

The Niners enter Week 4 undefeated and leading the league in yards per play and total touchdowns.

Their high-octane offense will clash with the Broncos’ defense at Levi’s Stadium, where the 49ers are 2.5-point favorites Sunday.

Broncos vs. 49ers prediction, best bet

There’s a lot to like about what the 49ers are doing this season.

They kicked things off in Australia with a dominant win over the Rams and haven’t trailed since the second quarter of that Week 1 game.

Brock Purdy is playing like an MVP and his odds reflect it.

The Niners’ QB opened at 20/1 in the offseason, then jumped to the second choice on the board at +450 behind Josh Allen after three games.

He’s barely made a mistake this season with 10 total touchdowns and one interception to go along with a league-leading 63.9 percent Success Rate.

It’s a stark contrast from what Bo Nix has displayed in his first three games.

Bo Nix of the Denver Broncos. Getty Images

Nix has left a lot to be desired even in Broncos wins.

He’s engineered two fourth-quarter comebacks, but it’s more concerning that the Broncos are digging themselves into huge holes with all the weapons they have to complement him.

---

Betting on the NFL?

• Read our expert guide on how to bet on the NFL
• Check out the best NFL betting sites
• Get the BetMGM Bonus Code

---

The Broncos are scoring a league-worst 3.3 points per game in the first half. If that stood over a full season, it would easily rank as the lowest first-half average since at least 2003.

At some point the Broncos will find their footing, but the Niners are already humming.

I’ll bet on a fast start from Purdy and the Niners at home.

The Pick: 49ers -1.5 1H (-105, DraftKings)

---

Why Trust New York Post Betting

Malik Smith has been immersed in the sports betting industry since 2017. He’s a data nerd with a particular focus on the NBA and combat sports. He spends his weeknights in the winter looking for edges on plus-money NBA player props.