Effect of perinatal ampicillin or amoxicillin/clavulanate exposure on maternal and infant gut microbiome, metabolome, and infant responses to the 20-valent pneumococcal conjugate vaccine

Дата публикации: 27-08-2026 00:00:00

Emerging studies suggest that antibiotics can disrupt the gut microbiome and alter vaccine-induced immune responses. However, the specific consequences of early-life exposure on neonatal immune development remain poorly understood. Here, we examined how two antibiotics frequently used in perinatal care, broad-spectrum ampicillin (AMP) and the extended-spectrum combination amoxicillin/clavulanate (AMOX/CLAV), administered during gestation and lactation, influence neonatal gut microbiome composition, fecal metabolome profiles, and responses to the 20-valent pneumococcal conjugate vaccine (PCV20). Maternal treatment with AMOX/CLAV, but not AMP, significantly reduced PCV-specific IgG titers at 4 and 6 weeks post-prime immunization compared to untreated controls. Exclusive exposure to AMOX/CLAV also impaired neutrophil-mediated opsonophagocytic killing, indicating reduced antibody functionality. These effects were transient, with immune parameters normalizing by 8 weeks post-prime...

Схожие новости

#	Наименование новости	Тональность	Информативность	Дата публикации
1	Lab Digs Into Prevotella’s Defensive Power Against Bacterial Pneumonia	0	13.69	11-08-2026
2	RSV Immunization With RSVpreF and Nirsevimab	0	13.58	01-08-2026
3	Trial supports switch from IV to oral antibiotics for kids with severe pneumonia	0	7.9	27-07-2026
4	Moms who receive COVID, flu vaccines during pregnancy more likely to vaccinate their babies, study says	0	8.92	16-07-2026
5	Antibiotic resistance is rising in invasive E coli found in US newborns, study finds	0	6.4	04-05-2026
6	Integrating GIS and Genomics for AMR One Health Drug Target Discovery in Imipenem-Resistant Escherichia coli [version 3; peer review: 1 approved, 1 not approved]	0	12.09	10-07-2026
7	Community reservoir of drug-resistant Klebsiella emerges across U.S., analysis shows	0	7	18-06-2026
8	Newborns protected from E coli infections by microbes from mom, study suggests	0	6.87	20-03-2026
9	Exploring the evolution of multidrug resistance patterns in ESKAPEE pathogens using association mining: Key to antibiotic stewardship? [version 3; peer review: 3 approved with reservations]	0	10.12	17-07-2026
10	Comparison between the new Xpert <i>Mycobacterium tuberculosis/</i>Rifampicin (MTB/RIF) Ultra assay and Xpert MTB/RIF for diagnosis of extra-pulmonary tuberculosis in a tertiary care center.	0	9.43	27-08-2026

Классификация: . Схожих патентов: 0. Схожих новостей: 10. Тональность: 0. Информативность: 7.84. Источник: escholarship.org.