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Pegylation of Zinc-Doped Copper Ferrite Nanoparticles for Biomedical Applications
Дата публикации: 29-07-2026 22:00:00

Publication date: 30 July 2026
Source: Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 73
Author(s): Ogheneochuko D. Oyaide, Christian Nwabunwanne, Lewis F. Obagboye, Samson O. Aisida, Fabian I. Ezema, Cem Bulent Ustundag
Zinc-substituted copper ferrite (Cu1-xZnxFe2O4) nanocomposites were synthesized in a polyethylene glycol (PEG) matrix via a sol–gel auto-combustion method to enhance biocompatibility and functional performance. Structural, optical, morphological, and magnetic properties were systematically investigated using XRD, FTIR, SEM, EDS, UV–Vis spectroscopy, and VSM. XRD confirmed a single-phase inverse spinel cubic structure, with crystallite sizes decreasing from 14.63 nm (pristine) to 9.14, 8.21, and 9.90 nm for x = 0.2, 0.4, and 0.6, respectively, based on the Williamson–Hall method. A slight reduction in bandgap energy (3.56–3.52 eV) was observed with increasing Zn content. FTIR analysis verified PEG functionalization, indicating improved stability and biocompatibility. SEM images revealed agglomerated nanostructures with rough surfaces, promoting reactive oxygen species generation and metal ion (Cu2+/Zn2+) release, which are beneficial for antimicrobial activity. Magnetic measurements demonstrated superparamagnetic behavior with near-zero coercivity, supporting biomedical applicability. The nanocomposites exhibited enhanced antibacterial and antifungal activities compared to standard drugs (cefixime and clotrimazole), with stronger effects against fungal strains. Additionally, notable antioxidant activity was observed. These findings highlight the potential of PEG-assisted Zn-substituted copper ferrite nanocomposites as multifunctional materials for antimicrobial and antioxidant biomedical applications.


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[1] N.G. and S. M.K, "Role of ferrite nanoparticles in hyperthermia applications," Journal of Magnetism and Magnetic Materials, vol. 552, p.169236, 2022.

DOI: 10.1016/j.jmmm.2022.169236

Google Scholar

[2] M. Jamir, R. Islam, L. Pandey and J. Borah, "Effect of surface functionalization on the heating efficiency of magnetite nanoclusters for hyperthermia application," J. Alloys Compd. , vol. 854, p.157248, 2021.

DOI: 10.1016/j.jallcom.2020.157248

Google Scholar

[3] A. Adil, O. Joseph, O. A. Samson, A. Chawki, I. Shumaila and I. E. Fabian, "Therapeutic and Photodegradation Applications of PVA, PVP and PEG Capped Ni x Co 1-x Fe 2 O 4 Nanoparticles by a Hydrothermal Method," Journal of Macromolecular Science, Part B, vol. 2024, pp.1-17, 2024.

DOI: 10.1080/00222348.2024.2367345

Google Scholar

[4] N.-u.-H. Khan, Z. A. Gilani, M. K. Samiullah, H. M. N. u. H. K. Asghar, M. Z. Nawaz, S. M. Ali, M. A. Khan and F. A. Sheikh, "Optical and magnetic studies of Co0. 7Zn0. 3Fe2O4 spinel ferrites with Dy3+ substituted for the application of sensors prepared through sol–gel process," Appl. Phys. A, vol. 130, p.1–15, 2024.

DOI: 10.1007/s00339-024-07476-w

Google Scholar

[5] A. V. Gongal, D. V. Nandanwar, D. S. Badwaik, S. S. Wanjari, V. S. Harode and S. M. Suryawanshi, "Study on multifunctional magnesium copper zinc spinel ferrite nanoparticles prepared by hydrothermal route; Physical, electrical, and anti-microbial investigation," Nano-Structures and Nano-Objects, vol. 39, p.101248, 2024.

DOI: 10.1016/j.nanoso.2024.101248

Google Scholar

[6] A. Nigam and S. J. Pawar, "Structural, magnetic, and antimicrobial properties of zinc doped magnesium ferrite for drug delivery applications," Ceramics International, vol. 46, pp.4058-4064, 2020.

DOI: 10.1016/j.ceramint.2019.10.243

Google Scholar

[7] R. B. Asamoah, A. Yaya, B. Mensah, P. Nbalayim, V. Apalangya, Y. D. Bensah, L. Damoah, B. Agyei-Tuffour, D. Dodoo-Arhin and E. Annan, "synthesis and characterization of zinc and copper oxide nanoparticles their antibacteria activity," ESSEVIER, p.1000099, 2020.

DOI: 10.1016/j.rinma.2020.100099

Google Scholar

[8] E. Glazkova, O. Bakina, N. Rodkevich, A. Mosunov and E. Vornakova, "Copper ferrite/copper oxides (I, II) nanoparticles synthesized by electric explosion of wires for high performance photocatalytic and antibacterial applications," Materials Science and Engineering B, vol. 283, p.115845, 2022.

DOI: 10.1016/j.mseb.2022.115845

Google Scholar

[9] B. Kumar, B. Borah, N. Babu and L. R. Chowhan, "Direct Michael addition/decarboxylation reaction catalyzed by a composite of copper ferrite nanoparticles immobilized on microcrystalline cellulose: an eco-friendly approach for constructing 3,4-dihydrocoumarin frameworks," RSC Advances, vol. 12, pp.30704-30711, 2022.

DOI: 10.1039/d2ra05994k

Google Scholar

[10] K. Muthukumar, D. S. Lakshmi, S. D. Acharya and S. Natarajan, "Solvothermal synthesis of magnetic copper ferrite nano sheet and its antimicrobial studies," Materials Chemistry and Physics, vol. 209, pp.172-179, 2018.

DOI: 10.1016/j.matchemphys.2018.02.004

Google Scholar

[11] K. Gurushantha, B. Swetha, S. Chinnam, K. Keshavamurthy, S. Meena, B. S. Surendra, S. Malini and K. P. Roopa, "Structural, Optical, Photocatalytic, and antimicrobial attributes of niobium substituted copper nanoferrites," Inorganic Chemistry Communications, vol. 156, p.111162, 2023.

DOI: 10.1016/j.inoche.2023.111162

Google Scholar

[12] K. Ganguly, P. Mahapatra, C. Mohanty, C. Das, A. Samal, R. K. Sahu and N. Das, "Multifunctional silver-doped strontium hexaferrite nanoparticles: Magnetic, optical, photocatalytic, and antimicrobial properties," Chemistry of Inorganic Materials, vol. 5, p.100098, 2025.

DOI: 10.1016/j.cinorg.2025.100098

Google Scholar

[13] D. V. Krishna, M. R. Sankar, P. V. G. K. Sarma and E. L. Samundeshwari, "Synergistic effects of Psidium guajava and copper nanoparticles reinforced hybrid Hydrogel for tissue engineering," Advanced Industrial and Engineering Polymer Research, vol. 8, pp.264-278, 2025.

DOI: 10.1016/j.aiepr.2024.10.001

Google Scholar

[14] B. Jyothish and J. Jacob, "Silver-doped zinc ferrite nanoparticles induce oxidative stress and exhibit differential cytotoxicity in lung, breast, liver, and colorectal cancer cells," Journal of Alloys and Compounds Communications, vol. 8, p.100114, 2025.

DOI: 10.1016/j.jacomc.2025.100114

Google Scholar

[15] N. Christian, O. A. Samson, A. M. Hisham, B. Subelia, A. Chawki, A. Adil and I. E. Fabian, "Chitosan, Alginate and Polyethylene Glycol Capped Zinc Oxide Nanoparticles for Hyperthermia Applications," Journal of Macromolecular Science, Part B , vol. 2024, pp.1-17, 2024.

DOI: 10.1080/00222348.2024.2413805

Google Scholar

[16] N. Madubuonu, S. O. Aisida, I. Ahmad, S. Botha, T.-k. Zhao, M. Maaza and F. I. Ezema, "Bio-inspired iron oxide nanoparticles using Psidium guajava aqueous extract for antibacterial activity," Appl. Phys. A, vol. 176, p.72, 2020.

DOI: 10.1007/s00339-019-3249-6

Google Scholar

[17] S. O. Aisida, M. Hisham, Alnasir, S. Botha, A. K. H. Bashir, R. Bucher, I. Ahmad, T.-k. Zhao, M. Maaza and F. I. Ezema, "The role of polyethylene glycol on the microstructural, magnetic and specific absorption rate in thermoablation properties of Mn-Zn ferrite nanoparticles by sol-gel protocol," European Polymer Journal, vol. 132, p.109739, 2020 .

DOI: 10.1016/j.eurpolymj.2020.109739

Google Scholar

[18] P. Smitha, I. Singh, M. Najim, R. Panwar, D. Singh, V. Agarwala and G. D. Varma, "Development of thin broad band radar absorbing materials using nanostructured spinel ferrites," J. Mater. Sci. Mater. Electron., vol. 27, p.7731–7737, 2016.

DOI: 10.1007/s10854-016-4760-6

Google Scholar

[19] F. Zhang, S. Kantake, Y. Kitamoto and M. Abe, "Spin-spray ferrite-plated co ferrite films with high coercivity for perpendicular magnetic recording media," IEEE Trans. Magn., vol. 35, p.2751–2753, 1999.

DOI: 10.1109/20.800974

Google Scholar

[20] A. Gonchar, V. Andreev, L. Letyuk, A. Shishkanov and V. Maiorov, "Problems of increasing of thermostability of highly permeable Ni-Zn ferrites and relative materials for telecommunications," J. Magn. Magn. Mater. , vol. 254–255, p.544–546, 2003.

DOI: 10.1016/s0304-8853(02)00860-0

Google Scholar

[21] F. Tudorache, E. Rezlescu, P. Popa and N. Rezlescu, "Study of some simple ferrites as reducing gas sensors," J. Optoelectron. Adv. Mater., vol. 10, p.1889–1893, 2008.

Google Scholar

[22] Aisida, P. A. Akpa, I. Ahmad, M. Maaza and F. I. Ezema, "Influence of PVA, PVP and PEG doping on the optical, structural, morphological and magnetic properties of zinc ferrite nanoparticles produced by thermal method," Physica B: Condensed Matter, vol. 571, p.130–136, 2019.

DOI: 10.1016/j.physb.2019.07.001

Google Scholar

[23] S. o. Aisida, M. H. Alnasir, S. Botha, A. K. Bashir and R. A. Bucher, "The role ofpolyethylene glycol on the microstructural, magnetic and specific absorption rate inthermoablation properties of Mn-Zn ferrite nanoparticles by sol-gel protocol.," European Polymer journal, vol. 132, no. 109739, 2020.

DOI: 10.1016/j.eurpolymj.2020.109739

Google Scholar

[24] S. O. Aisida, C. Onwujiobi, I. Ahmad, T.-k. Zhao, M. Maaza and F. I. Ezema, "Biogenic synthesis of zinc oxide nanorods for biomedical applications and photodegradation of Rhodamine B," Materials Today Communications , vol. 33, p.104660, 2022.

DOI: 10.1016/j.mtcomm.2022.104660

Google Scholar

[25] Aisida, A. Ali, O. E. Oyewande, I. Ahmad, A. Ul-hamid and T. Zhao, "Biogenic synthesis enhanced structural, morphological, magnetic and optical properties of zinc ferrite nanoparticles for moderate hyperthermia applications," J. Nanopart Res., vol. 23, p.47, 2021.

DOI: 10.1007/s11051-021-05149-w

Google Scholar

[26] E. Blessed, O. A. Samson, A. N. M. Hisham, A. Chawki, A. Adil and I. E. Fabian, "Manganese Doped Zinc Oxide Nanoparticles Capped with Chitosan, Cetyltrimethylammonium Bromide and Gongronema latifolium for Hyperthermia Applications," Journal of Macromolecular Science, Part B , vol. 2024, pp.1-23, 2024.

DOI: 10.1080/00222348.2024.2425562

Google Scholar

[27] K. M. Batoo and M.-S. A. El-sadek, "Electrical and magnetic transport properties of Ni–Cu–Mg ferrite nanoparticles prepared by sol–gel method," J. Alloy. Compd., vol. 566, p.112–119, 2013.

DOI: 10.1016/j.jallcom.2013.02.129

Google Scholar

[28] C. R. Vestal and Z. Zhang, "Magnetic spinel ferrite nanoparticles from microemulsions," Int. J. Nanotechnol., vol. 1, p.240–263, 2004.

Google Scholar

[29] N. P. Devi and M. Maisnam, "Characterizations of sol-gel synthesized and high energy ball milled spinel nanoferrites: MFe2O4 (M= Li, Ni, Zn, Mn) for nanofluid preparations," Integr. Ferroelectr., vol. 204, p.133–141, 2020.

DOI: 10.1080/10584587.2019.1674972

Google Scholar

[30] M. Gonzalez-Sandoval, A. Beesley, M. Miki-Yoshida, L. Fuentes-Cobas and J. A. Matutes-Aquino, "Comparative study of the microstructural and magnetic properties of spinel ferrites obtained by co-precipitation,," J. Alloy. Compd., vol. 369, p.190–194, 2004.

DOI: 10.1016/j.jallcom.2003.09.101

Google Scholar

[31] S. Mohapatra, S. Rout, S. Maiti, T. Maiti and A. Panda, "Monodisperse mesoporous cobalt ferrite nanoparticles: Synthesis and application in targeted delivery of antitumor drugs," J. Mater. Chem., vol. 21, p.9185–9193, 2011.

DOI: 10.1039/c1jm10732a

Google Scholar

[32] D. Kim, D. Nikles and C. Brazel, "Synthesis and characterization of multifunctional chitosan-MnFeO4 nanoparticles for magnetic hyperthermia and drug delivery," Materials, vol. 3, p.4051–4065, 2010.

DOI: 10.3390/ma3074051

Google Scholar

[33] S. O. Aisida, T. C. Chibueze, M. HAlnasir, O. E. Oyewande, A. T. Raji, C. E. Ekuma, I. Ahmad, T.-k. Zhao, M. Maaza and F. I. Ezema, "Microstructural and magneto-optical properties of Co1-xNix Fe2O4 nanocomposites for hyperthermia applications," Solid State Sciences, vol. 136, p.107107, 2023.

DOI: 10.1016/j.solidstatesciences.2022.107107

Google Scholar

[34] M. Atif, S. K. Hasanain and m. Nadeem, "Magnetization of sol-gel prepared with zinc ferrite nanoparticles: Effects of inversion and paerticle size.," solid state communications, vol. 138, pp.416-421, 2006.

DOI: 10.1016/j.ssc.2006.03.023

Google Scholar

[35] O. K. Mmelesi, R. Patala, T. T. Nkambule, B. B. Mamba, K. K. Kefeni and A. T. Kuvarega, "Effect of Zn doping on physico-chemical properties of cobalt ferrite for the photodegradation of amoxicillin and deactivation of E. coli," Colloids and Surfaces A: Physicochemical and Engineering A spects, vol. 649, p.129462, 2022.

DOI: 10.1016/j.colsurfa.2022.129462

Google Scholar

[36] A. Nigama, S. Sainib, B. Singhb, A. K. Raib and S. Pawar, "Zinc doped magnesium ferrite nanoparticles for evaluation of biological properties viz antimicrobial, biocompatibility, and in vitro cytotoxicity," Materials Today Communications, vol. 31, p.103632, 2022.

DOI: 10.1016/j.mtcomm.2022.103632

Google Scholar

[37] I. Haq, A. Mannan, I. Ahmed, I. Hussain, M. Jamil and B. Mirza, "Antibacterial activity and brine shrimp toxicity of Artimisia dubia extract.," Pakistan Journal of Botany, vol. 44, pp.1487-1490, 2012.

Google Scholar

[38] S. Khan, T. Rehman, B. Mirza, I. Haq and M. Zia, "Antioxidant, antimicrobial, cytotoxic and protein kinase inhibition activities of fifteen traditional medicinal plants from Pakistan.," Journal of Pharmaceutical Chemistry, vol. 51, pp.391-398, 2017.

DOI: 10.1007/s11094-017-1620-5

Google Scholar

[39] D. Nath, F. Singh and R. Das, "X-ray diffraction analysis by Williamson-Hall, Halder-Wagner and size-strain plot methods of CdSe nanoparticles -a comparative study," Mater. Chem Phys., vol. 239, p.122021, 2020.

DOI: 10.1016/j.matchemphys.2019.122021

Google Scholar

[40] A. Batool, S. O. Aisida, R. Javed, M. mushtaq, C. O. Ugwuoke, J. S. Ali, H. Albalawi, I. Ahmad, T.-k. Zhao and F. I. Ezema, "PEG Capped NixCo1−xFe2O4 Nanocomposites: Microstructural, Morphological, Optical, Magnetic, Antimicrobial, and Photodegradable Properties," BioNanoScience, vol. 13, pp.1-12, 2023.

DOI: 10.1007/s12668-023-01064-7

Google Scholar

[41] T.R. Tatarchuk, N.D. Paliychuk, M. Bououdina, B. Al-Najar, M. Pacia, W. Macyk and A. Shyichuk, "Effect of cobalt substitution on structural, elastic, magnetic and optical properties of zinc ferrite nanoparticles," Journal of Alloys and Compounds, vol. 731 , pp.1256-1266, 2018.

DOI: 10.1016/j.jallcom.2017.10.103

Google Scholar

[42] S. O. Aisida, M. H. Alnasir, S. Botha, A. K. Bashir, R. Bucher, A. I. and F. I. . . . Ezema, "The role of polyethylene glycol on the microstructural, magnetic and specific absorption rate in thermoablation properties of Mn-Zn ferrite nanoparticles by sol-gel protocol.," European Polymer Journal, vol. 109739, p.132, 2020b.

DOI: 10.1016/j.eurpolymj.2020.109739

Google Scholar

[43] C. E. Arinzechekwu, S. O. Aisida, A. Agbogu, I. Ahmad and F. I. Ezema, "Polyethylene glycol capped nickel – zinc ferrite nanocomposites: structural, optical and magnetic properties suitable for hyperthermia applications," Applied Physics A, pp.1087-1095, 2022.

DOI: 10.1007/s00339-022-06248-8

Google Scholar

[44] R. Javed, M. Usman, S. Tabassum and M. Zia, "Effect of capping agents: Structural, optical and biological properties of ZnO nanoparticles," Applied Surface Science, vol. 386, no. 15, pp.319-326, 2016.

DOI: 10.1016/j.apsusc.2016.06.042

Google Scholar

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