The latest alleged ransom note sent to TMZ in connection to Nancy Guthrie’s disappearance suggests several people were involved in her abduction – and that one of them has fled the US.

In an email sent to the outlet on Friday afternoon, the sender said law enforcement should “be prepared to go international” in order to locate the “main individual” behind the baffling Guthrie case, TMZ reported.

The author of the email — the third one sent to TMZ on the same day — claimed to know the identity of the 84-year-old woman’s abductor and said he knows her current condition.

The latest ransom note suggests that several people were involved in Nancy Guthrie’s abduction.

The ransom price for information about the case was also upped, from the 1 bitcoin — worth about $68,000 — to the $100,000 FBI reward.

The person behind the ransom emails said they are contacting TMZ as an “intermediary” because he doesn’t trust law enforcement, telling authorities, “You don’t trust me, and I don’t trust you,” TMZ reported.

The latest ominous ransom letter comes as the frantic search for Guthrie, mom of “Today” show anchor Savannah Guthrie, and her captor entered its 13th day.

Authorities have not identified any suspects behind the kidnapping, in which the elderly grandmother seems to have been forced from her Arizona home, leaving a trail of blood behind.

She was last seen at her Tucson home on Jan. 31, when she was driven home by her son-in-law, Tommaso Cioni, after having dinner with him and her daughter, Annie.

The note also suggests that one of the alleged abductors has fled the United States. X/Erin Burnett OutFront Nancy Guthrie has been missing since February 1. savannahguthrie/Instagram

Local authorities have been asking residents within a 2-mile radius of Nancy’s Tucson home to check for any suspicious footage throughout the entire month of January — and are urging anyone with information to come forward.

On Thursday, the FBI released a description of an armed person caught on Guthrie’s Nest camera luring at her front door.

The alleged abductor is described as a male, approximately 5 feet 9 inches to 5 feet 10 inches tall, with an average build — and was seen wearing a 25-liter Ozark Trail Hiker Pack backpack in the original doorbell footage, according to the feds.

Pima County investigators on Friday also recovered DNA evidence from somebody not known to be “in close” contact with Guthrie, from her property.

The unidentified DNA was sent to a laboratory for analysis.

The feds doubled the reward to $100,000 for information leading to Guthrie or her captor.