The findings of a new study imply that genome-wide association studies — an increasingly popular kind of study that looks for the genetic variants linked to diseases — may be missing a significant fraction of heritable variation because that variation is not in the sequence

Representation of a DNA molecule that is methylated. The two white spheres represent methyl groups. They are bound to two cytosine nucleotide molecules that make up the DNA sequence. | Photo Credit: Christoph Bock (CC BY-SA)
A team led by researchers at the Johns Hopkins School of Medicine has found that several inherited traits in the mouse genome break the rules Gregor Mendel laid down in the 19th century about how genes work. This is not because the genes mutate but because of chemical modifications of the genome that can jump across generations, change depending on whether an animal is male or female, and even copy themselves from one copy of a gene to another.
Their findings were reported recently in Nature Genetics.
Published - August 10, 2026 09:00 am IST
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