George Clooney showed he hasn't lost his mischievous side as he put on a cheeky display at the star-studded London premiere of his new Netflix film Jay Kelly on Friday evening.

The Hollywood heartthrob, 64, couldn't resist getting handsy on the red carpet,  jokingly grabbing the behinds of producer David Heyman, 64, and director Noah Baumbach, 56, as the trio posed up a storm outside the Royal Festival Hall.

The actor, who plays movie star Jay Kelly in the upcoming Netflix film opposite Adam Sandler, looked as suave as ever in a navy tuxedo and black leather shoes.

Of course, wife Amal Clooney, 47, was on hand to support her husband and ensured all eyes were on her in a breathtaking metallic gown with feathered sleeves. 

The power couple looked effortlessly glamorous as they worked the red carpet together, posing up a storm for the cameras.

Jay Kelly sees George taking on the role of a movie star who 'always plays himself'.

In the first trailer for the film, the actor is seen questioning his life choices, despite being fawned over by fans and staff.

On a trip to an Italian film festival in his honour, joined by his manager, played by Adam, he's hailed as the 'hero of cinema' before being brutally asked about always playing himself.

To which he snaps back: 'You know how difficult it is to be yourself? You try it.'

George's character is seen continually reminding himself that he is 'Jay Kelly' as he and his pal embark on a whirlwind trip through Europe, as it appears the glamour of showbiz has lost its appeal.

The movie is directed by Greta's husband and fellow Barbie scribe Noah Baumbach, who wrote the script alongside British actress Emily Mortimer.

The official synopsis reads: 'Two middle-aged friends rediscover their youthful spirit during a chaotic weekend reunion, facing hilarious mishaps and heartfelt moments that force them to finally grow up.'

George has had an illustrious career spanning 40 years, in which he's bagged an Academy Award for his role in Syriana in addition to a wealth of other accolades.

But during a recent interview with Variety, the Ocean's 11 star was asked about the doubts about his range as an actor, with George furiously snapping back: 'Do people say that I only play myself? I don't give a sh*t.'

He went on: 'There aren't that many guys in my age group that are allowed to do both broad comedies like O Brother [Where Art Though?] and then do Michael Clayton or Syriana. So if that means I'm playing myself all the time, I don't give a sh*t.'

Echoing a quote from his character in the upcoming project, Jay Kelly, he added: Have you ever tried playing yourself? It's hard to do.'

The Hollywood hunk continued: 'I've been the beneficiary of having my career not be massively successful in lots of different directions. 

'I didn't really get successful, in the kind of success that can be blinding, until I was 33 years old [when ER began]. I'd been working for 12 years at that point. 

'I had a real understanding of how fleeting all of it is and how little it has to do with you, quite honestly.'

Jay Kelly will be released in select theatres on November 14 before being available for streaming on Netflix on December 5.