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The Cure Starts Now Funds $1 Million Big Fat Grant to Advance CAR T Cell Therapy for Childhood Brain Cancer

Дата публикации: 08-09-2025 18:40:51

<div class="embed-container"><iframe src="https://www.youtube.com/embed/76_lgvaIxTQ" frameborder="0" allowfullscreen=""></iframe></div> <p>The Cure Starts Now Foundation and their partners The DIPG/DMG Collaborative today announced a $1 million research grant to support a joint project led by&nbsp;<strong>Seattle Children’s Hospital and St. Jude Children’s Research Hospital</strong>. The award, the foundation’s “Big Fat Grant,” will accelerate development of promising new strategies to treat <a href="https://dipg.org/facts/what-is-dmg/" title="What is DMG">diffuse midline glioma (DMG)</a>, one of the most aggressive childhood brain cancers.&nbsp;</p> <p>This is the second year in a row the foundation has awarded this grant, a direct result of the generosity of its donors. This is the fourth largest grant awarded by the charity in its 18-year history. This landmark project builds on an ongoing clinical trial using B7-H3 CAR T cell therapy for DMG.&nbsp;</p> <p>With this new funding, researchers will explore ways to improve the tumor immune microenvironment, preparing it to better respond to treatment. By testing pre-treatment strategies such as radiation and laboratory-validated approaches, the team aims to create conditions that allow CAR T cells to work more effectively and deliver stronger, longer-lasting responses.</p> <blockquote>“The $1,000,000 Big Fat Grant is all about big ideas,” said Brooke Desserich, Co-Founder and Executive Director of The Cure Starts Now. “By funding this innovative work, we’re helping to push the boundaries of what is possible for children facing DMG, while laying a foundation for breakthroughs across all brain cancers.”</blockquote> <p>The Cure Starts Now has raised over <strong>$37.5 million</strong> in cancer research and support across 80 institutions worldwide in tandem with the DIPG/DMG Collaborative. This latest grant reflects the foundation’s commitment to driving forward bold, collaborative research with the potential to unlock the universal cure for cancer.</p>

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